Head Coach: Mark Stoops
Record: 5–7
SEC Record: 2–6
| Date | Opponent | Location | Score (UK first) |
|---|---|---|---|
| Aug 30 | Toledo | Kroger Field Lexington | W 24–16 |
| Sep 6 | #20 Ole Miss | Kroger Field Lexington | L 23–30 |
| Sep 13 | Eastern Michigan | Kroger Field Lexington | W 48–23 |
| Sep 27 | South Carolina | Williams-Brice Stadium Columbia | L 13–35 |
| Oct 4 | #12 Georgia | Sanford Stadium Athens | L 14–35 |
| Oct 18 | #21 Texas | Kroger Field Lexington | L 13–16 (OT) |
| Oct 25 | #17 Tennessee | Kroger Field Lexington | L 34–56 |
| Nov 1 | Auburn | Jordan-Hare Stadium Auburn | W 10–3 |
| Nov 8 | Florida | Kroger Field Lexington | W 38–7 |
| Nov 15 | Tennessee Tech | Kroger Field Lexington | W 42–10 |
| Nov 22 | #12 Vanderbilt | FirstBank Stadium Nashville | L 17–45 |
| Nov 29 | Louisville | L&N Stadium Louisville | L 0–41 |
Source: UK Athletics’ 2025 football schedule.