Kentucky’s series record 4–1. Scores list Kentucky first.
| Date | Game | Result | Score | Notes |
|---|---|---|---|---|
| Aug. 31, 2024 | Southern Miss at Kentucky | W | 31–0 | Box score |
| Sept 2, 2017 | Kentucky at Southern Miss | W | 24–17 | Hattiesburg · Box score |
| Sept 3, 2016 | Southern Miss at Kentucky | L | 35–44 | Box score |
| Oct 4, 1986 | Southern Miss at Kentucky | W | 32–0 | — |
| Sept 17, 1949 | Southern Miss at Kentucky | W | 71–7 | — |
Game results come from the Kentucky football season archive. Box scores are linked where a game-specific source was verified.